Westenberg H G, de Zeeuw R A, van de Kleijn E, Oei T T
Clin Chim Acta. 1977 Aug 15;79(1):155-61. doi: 10.1016/0009-8981(77)90473-9.
The concentration of carbamazepine in plasma and saliva was determined in 7 subjects receiving carbamazepine. Plasma and saliva samples were assayed was an excellent linear relationship between carbamazepine concentrations in saliva and plasma (r = 0.991, p less than 0.001) over a plasma concentration range of 0.2--8.0 microgram/ml. The saliva/plasma ratio for carbamazepine was 0.26 +/- 0.02 (S.D.). Since carbamazepine binding to plasma proteins is in the order of 75%, the saliva concentration seems to reflect the concentration of the free drug in plasma. There is very little intrasubject and intersubject variation in the concentration ratio of carbamazepine. This study demonstrates that carbamazepine determination in saliva is a convenient method for optimizing blood levels of patients as well as for the study of pharmacokinetic properties.
对7名接受卡马西平治疗的受试者测定了血浆和唾液中卡马西平的浓度。对血浆和唾液样本进行了分析，在血浆浓度范围为0.2 - 8.0微克/毫升时，唾液和血浆中卡马西平浓度之间存在极好的线性关系（r = 0.991，p小于0.001）。卡马西平的唾液/血浆比值为0.26±0.02（标准差）。由于卡马西平与血浆蛋白的结合率约为75%，唾液浓度似乎反映了血浆中游离药物的浓度。卡马西平浓度比值在受试者内和受试者间的变化很小。本研究表明，测定唾液中的卡马西平是优化患者血药浓度以及研究药代动力学特性的一种便捷方法。
