Takahashi T, Munakata M, Takekawa H, Homma Y, Kawakami Y
First Department of Medicine School of Medicine, Hokkaido University, Sapporo, Japan.
Am J Ind Med. 1996 Nov;30(5):596-600. doi: 10.1002/(SICI)1097-0274(199611)30:5<596::AID-AJIM7>3.0.CO;2-R.
A 56-year-old male carpenter had a history of glass fiber inhalation for 41 years without any protective device. His chest radiograph showed small nodular opacities in lower lung fields and multiple cystic lesions and low attenuation areas in upper lung fields. Light and polarizing microscopic examinations of his transbronchial lung biopsy specimen revealed mild interstitial fibrosis and mononuclear cell infiltration in alveolar walls without birefringent substances. However, widespread depositions of small glass fibers (< 2.5 microns in length and 0.3 micron in diameter) were detected by analytical electron microscopy, which suggested their possible contribution to the development of his pulmonary fibrosis.
一名56岁的男性木匠，在没有任何防护设备的情况下有41年的玻璃纤维吸入史。他的胸部X光片显示下肺野有小结节状阴影，上肺野有多个囊性病变和低密度区。对其经支气管肺活检标本进行光镜和偏振光显微镜检查，发现肺泡壁有轻度间质纤维化和单核细胞浸润，未见双折射物质。然而，通过分析电子显微镜检测到广泛存在的小玻璃纤维沉积（长度<2.5微米，直径0.3微米），这表明它们可能与他的肺纤维化发展有关。
