人脑脊液中游离及总3-甲氧基-4-羟基苯乙二醇：与高血压患者及神经精神疾病患者血压的关系

Free and total 3-methoxy-4-hydroxyphenylethylene glycol in human cerebrospinal fluid: relationship to blood pressure in hypertensives and patients with neuropsychiatric disease.

作者信息

Murray S, Jones D H, Davies D S, Dollery C T, Reid J L

出版信息

Clin Chim Acta. 1977 Aug 15;79(1):63-8. doi: 10.1016/0009-8981(77)90461-2.

Abstract

The concentrations of free and total 3-methoxy-4-hydroxyphenylethylene glycol (MHPG) in the cerebrospinal fluid of 43 patients were measured by selected ion monitoring gas chromatography-mass spectrometry using MHPG specifically labelled with deuterium as internal standard. Unpaired Wilcoxon comparisons of free and total MHPG concentrations in males and females showed no significant difference between the sexes. The relationships between free, conjugated and total MHPG concentrations and age, blood pressure, glucose and protein levels in cerebrospinal fluid were examined by linear regression analysis. The only significant correlations found were between free MHPG and glucose and between total MHPG and glucose.

摘要

采用以氘特异性标记的3-甲氧基-4-羟基苯乙二醇（MHPG）作为内标，通过选择离子监测气相色谱-质谱法测定了43例患者脑脊液中游离和总MHPG的浓度。对男性和女性的游离和总MHPG浓度进行非配对Wilcoxon比较，结果显示两性之间无显著差异。通过线性回归分析研究了游离、结合和总MHPG浓度与年龄、血压、脑脊液中葡萄糖和蛋白质水平之间的关系。发现的唯一显著相关性是游离MHPG与葡萄糖之间以及总MHPG与葡萄糖之间的相关性。