Bridgman J B, Gillgrass T G, Zacharias M
Department of Oral Medicine & Oral Surgery, School of Dentistry, University of Otago, Dunedin, New Zealand.
Br J Oral Maxillofac Surg. 1996 Oct;34(5):428-31. doi: 10.1016/s0266-4356(96)90101-1.
Pre-emptive analgesic efficacy of the non-steroidal anti-inflammatory drug, diclofenac sodium, was tested in 21 young, fit, patients undergoing third molar extractions in a double-blind, randomised, cross-over, trial. Pain scores and mouth opening were observed for 1 week after the operation and these did not show any differences following pre- and postoperative oral administration of diclofenac sodium 100 mg (P > 0.05). There were no differences in the patients' preference for the two methods of treatment (P > 0.05). The study suggests that the non-steroidal anti-inflammatory drug diclofenac sodium does not cause any significant pre-emptive analgesic effects in the dose administered.
在一项双盲、随机、交叉试验中，对21名年轻、健康、正在接受第三磨牙拔除术的患者测试了非甾体抗炎药双氯芬酸钠的超前镇痛效果。术后观察1周的疼痛评分和开口度，术前和术后口服100毫克双氯芬酸钠后，这些指标均未显示出任何差异（P>0.05）。患者对两种治疗方法的偏好没有差异（P>0.05）。该研究表明，非甾体抗炎药双氯芬酸钠在所给药剂量下不会产生任何显著的超前镇痛作用。
