P物质和甲硫氨酸脑啡肽对猫结肠平滑肌活动的影响。

Effect of substance P and met-enkephalin on cat colonic smooth muscle activity.

Atanassova E, Papasova M

Institute of Physiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.

Gen Pharmacol. 1996 Sep;27(6):1053-6. doi: 10.1016/0306-3623(95)02132-9.

Abstract

The effects of substance P (2.5 x 10(-8)M) (SP) and met-enkephalin (10(-7)M) (ME), when administered alone or in combination (SP + ME), on the contractile activity of cat colonic muscle strips were compared. 2. SP evoked powerful contractions of the circular muscle strips (2.30 +/- 0.36 g) (background 0.65 +/- 0.10 g). 3. In the majority of cases, ME significantly increased the background activity (1.88 +/- 0.34 g and 0.70 +/- 0.10 g, respectively). 4. The two substances administered together produced the most pronounced contractile activity (3.86 +/- 0.44 g). 5. The longitudinal muscle strips showed higher spontaneous and evoked contractions. 6. Thus ME contributes to the increase in the effect of SP on colonic contractile activity.

摘要

比较了单独给予或联合给予（P物质+甲硫氨酸脑啡肽）P物质（2.5×10⁻⁸M）（SP）和甲硫氨酸脑啡肽（10⁻⁷M）（ME）对猫结肠肌条收缩活性的影响。2. SP引起环形肌条强烈收缩（2.30±0.36g）（背景值0.65±0.10g）。3. 在大多数情况下，ME显著增加背景活性（分别为1.88±0.34g和0.70±0.10g）。4. 两种物质一起给予产生最明显的收缩活性（3.86±0.44g）。5. 纵行肌条显示出更高的自发收缩和诱发收缩。6. 因此，ME有助于增强SP对结肠收缩活性的作用。