Podar T, Solntsev A, Väli M, Vinogradova T, Podar I
Hospital of Endocrinology, Department of Internal Medicine, University of Tartu, Estonia.
Int J Obes Relat Metab Disord. 1996 Oct;20(10):921-4.
To evaluate whether weight cycling is detrimental to the changes in glucose tolerance in obese individuals without overt NIDDM and related to the amplitude of weight cycling.
Historical prospective observational study of a hospital-based cohort.
One hundred twenty-five obese individuals drawn from the medical records of the Hospital of Endocrinology, University of Tartu, in whom at least one weight cycle was detected. Selected cutoff value for weight cycling set to 3, 6, 9 and 12 kg of weight loss and subsequent regain.
Weight measurements and oral glucose tolerance tests. The latest oral glucose tolerance test and the one during the first visit compared by the 2 h blood glucose values and areas under the blood glucose curve.
No deterioration of glucose tolerance recorded in any of the groups with different cutoff values for weight cycling. No trend towards the deterioration of glucose tolerance with increasing amplitude of weight cycles.
We cannot claim that weight cycling is detrimental to glucose tolerance in non-diabetic obese individuals. This effect is independent of the amplitude of weight cycling. Weight reduction may be recommended to obese individuals for the prevention of NIDDM even if it is unsuccessful and the phenomenon of weight cycling results.
评估体重循环对无明显非胰岛素依赖型糖尿病的肥胖个体糖耐量变化是否有害，以及是否与体重循环幅度相关。
基于医院队列的历史性前瞻性观察研究。
从塔尔图大学内分泌医院的病历中选取125名肥胖个体，其中至少检测到一次体重循环。体重循环的选定临界值设定为体重减轻3、6、9和12千克及随后的体重恢复。
体重测量和口服葡萄糖耐量试验。通过2小时血糖值和血糖曲线下面积比较最新的口服葡萄糖耐量试验和首次就诊时的试验结果。
在体重循环不同临界值的任何组中均未记录到糖耐量恶化。未观察到随着体重循环幅度增加糖耐量恶化的趋势。
我们不能声称体重循环对非糖尿病肥胖个体的糖耐量有害。这种影响与体重循环幅度无关。即使减肥不成功且出现体重循环现象，也可建议肥胖个体进行减肥以预防非胰岛素依赖型糖尿病。
