Shimamura K, Matsuda K, Sekiguchi F, Sunano S
Research Institute of Hypertension, Kinki University, Osaka-Sayama, Japan.
J Smooth Muscle Res. 1996 Aug;32(4):145-54. doi: 10.1540/jsmr.32.145.
The influence of blood pressure and age of spontaneously hypertensive rats on endothelium-dependent tension oscillation of aortic preparation were studied. Rats with different blood pressures, normotensive Wistar Kyoto rats (WKY), spontaneously hypertensive rats (SHR), stroke-prone SHR (SHRSP) and malignant type of SHRSP (M-SHRSP), were used. The effects of antihypertensive treatment of SHRSP on the tension oscillation were also studied. High doses of noradrenaline induced tension oscillations in endothelium-intact preparations of all strains of young rats. The rate of the occurrence of the tension oscillation decreased age-dependently. The decrease was faster when the blood pressure of the rats was higher. Application of acetylcholine in the presence of noradrenaline induced a relaxation and tension oscillations, both of which were negatively dependent on age and blood pressure. Antihypertensive treatment of hypertensive rats with hydralazine or captopril prevented a decrease in incidence of the tension oscillation. These influences of age and blood pressure as well as antihypertensive treatments on the tension oscillation resembled those on the endothelium-dependent relaxation and are thought to be brought about by functional changes of the endothelium.
研究了自发性高血压大鼠的血压和年龄对主动脉标本内皮依赖性张力振荡的影响。使用了具有不同血压的大鼠，即正常血压的Wistar Kyoto大鼠（WKY）、自发性高血压大鼠（SHR）、易卒中型SHR（SHRSP）和恶性型SHRSP（M-SHRSP）。还研究了SHRSP的抗高血压治疗对张力振荡的影响。高剂量去甲肾上腺素在所有品系的年轻大鼠内皮完整的标本中诱导张力振荡。张力振荡的发生率随年龄依赖性降低。当大鼠血压较高时，这种降低更快。在去甲肾上腺素存在下应用乙酰胆碱诱导松弛和张力振荡，二者均呈负年龄和血压依赖性。用肼屈嗪或卡托普利对高血压大鼠进行抗高血压治疗可防止张力振荡发生率降低。年龄、血压以及抗高血压治疗对张力振荡的这些影响类似于对内皮依赖性舒张的影响，并且被认为是由内皮功能变化引起的。
