Martin R M, Colebrook A L, Gasser R B, Lightowlers M W
University of Melbourne, Department of Veterinary Science, Victoria, Australia.
Acta Trop. 1996 Aug;61(4):307-14. doi: 10.1016/0001-706x(96)00012-5.
Hydatid patients were investigated for the presence of specific serum antibodies against a recombinant Echinococcus granulosus antigen, designated myophilin. The clinical history of each patient was examined to determine any correlation between factors such as cyst location and medical treatment on the presence or absence of antibodies to myophilin. Specific antibodies against recombinant myophilin were detected by Western blot analysis in 38.8% (7 of 18) of the hydatid patients examined. These patients also had the highest titres in ELISA against sheep hydatid cyst fluid antigen. There was an association between the presence of antibodies to myophilin and the patients having undergone recent treatment by chemotherapy and/or surgery, suggesting that the destruction of hydatid cysts may lead to an immune response against myophilin.
对包虫病患者进行了检测，以确定其血清中是否存在针对一种名为肌动蛋白的重组细粒棘球绦虫抗原的特异性抗体。检查了每位患者的临床病史，以确定囊肿位置和治疗等因素与抗肌动蛋白抗体的存在与否之间是否存在任何关联。在所检查的18例包虫病患者中，有38.8%（7例）通过蛋白质印迹分析检测到了针对重组肌动蛋白的特异性抗体。这些患者在酶联免疫吸附测定中针对绵羊包虫囊肿液抗原的滴度也最高。抗肌动蛋白抗体的存在与近期接受化疗和/或手术治疗的患者之间存在关联，这表明包虫囊肿的破坏可能会引发针对肌动蛋白的免疫反应。
