三氟拉嗪在促使血红蛋白和肌红蛋白释放氧方面比氯丙嗪更有效。

Trifluoperazine is more effective than chlorpromazine in releasing oxygen from haemoglobin and myoglobin.

作者信息

Bhattacharyya J, Bhattacharyya M, Chakraborti A S, Chaudhuri U, Poddar R K

机构信息

Department of Biophysics, Molecular Biology & Genetics, University of Calcutta, India.

出版信息

J Pharm Pharmacol. 1996 Sep;48(9):965-7. doi: 10.1111/j.2042-7158.1996.tb06013.x.

DOI:10.1111/j.2042-7158.1996.tb06013.x

PMID:8910864

Abstract

The extent of oxygen release from two heme proteins, haemoglobin and myoglobin have been studied in the presence of trifluoperazine and chlorpromazine (5-1000 microM). At a molar ratio (drug:protein) of 1.5, the release of oxygen from haemoglobin was 4 and 15% in the presence of chlorpromazine and trifluoperazine respectively, while from myoglobin the corresponding values were 20 and 40%. The findings were attributed to the greater extent of local conformational change around tryptophan moieties of each of the proteins induced by trifluoperazine.

摘要

在三氟拉嗪和氯丙嗪（5 - 1000微摩尔）存在的情况下，研究了两种血红素蛋白——血红蛋白和肌红蛋白的氧释放程度。在摩尔比（药物：蛋白质）为1.5时，在氯丙嗪和三氟拉嗪存在的情况下，血红蛋白的氧释放率分别为4%和15%，而肌红蛋白的相应值分别为20%和40%。这些发现归因于三氟拉嗪诱导的每种蛋白质色氨酸部分周围局部构象变化的程度更大。