McCarty M F
Nutrition 21, San Diego, CA 92109, USA.
Med Hypotheses. 1996 Oct;47(4):269-72. doi: 10.1016/s0306-9877(96)90065-1.
The use of parenteral magnesium sulfate for the management of pre-eclampsia/eclampsia is well established. In striking analogy to the effects of hypermagnesemia, taurine has antivasospastic, antihypertensive, platelet-stabilizing, anticonvulsant and hypoxia-protective properties. Thus parenteral magnesium taurate can reasonably be proposed as a superior alternative to magnesium sulfate in the treatment of pre-eclampsia; administered orally as a component of prenatal supplementation, magnesium taurate might well have both preventive and therapeutic value in this syndrome. In the light of the hypoxia-protective actions of both magnesium and taurine, such supplementation might also protect fetuses experiencing temporary perinatal asphyxia, lessening the risk of cerebral palsy.
胃肠外使用硫酸镁治疗先兆子痫/子痫已得到充分确立。与高镁血症的作用极为相似,牛磺酸具有抗血管痉挛、降压、稳定血小板、抗惊厥和保护缺氧的特性。因此,胃肠外使用牛磺酸镁可合理地被提议作为治疗先兆子痫时硫酸镁的一种更优替代方案;作为产前补充剂的一部分口服给药时,牛磺酸镁很可能对该综合征具有预防和治疗价值。鉴于镁和牛磺酸都具有保护缺氧的作用,这种补充剂还可能保护经历短暂围产期窒息的胎儿,降低患脑瘫的风险。