Sibai B M
Department of Obstetrics and Gynecology, University of Tennessee, Memphis 38103.
Am J Obstet Gynecol. 1990 May;162(5):1141-5. doi: 10.1016/0002-9378(90)90002-o.
The pathogenesis of eclamptic convulsions is unknown. A review of the world literature indicates considerable controversy regarding the ideal anticonvulsant to prevent or control these convulsions. Parenteral magnesium sulfate is the drug of choice to control eclamptic convulsions in North America, but it is rarely used for this purpose overseas. The efficacy and safety of magnesium sulfate in the treatment of preeclampsia-eclampsia have been well documented during the past 60 years. During the same time period, numerous anticonvulsant drugs have been used overseas; however, the ideal drug is yet to be found. Recently phenytoin has been recommended as an alternative for magnesium sulfate; however, comprehensive data regarding its safety and efficacy are lacking. The evidence in the literature indicates that magnesium sulfate is the ideal anticonvulsant in preeclampsia-eclampsia.
子痫抽搐的发病机制尚不清楚。对世界文献的回顾表明，对于预防或控制这些抽搐的理想抗惊厥药物存在相当大的争议。在北美，静脉注射硫酸镁是控制子痫抽搐的首选药物，但在海外很少用于此目的。在过去60年中，硫酸镁治疗先兆子痫-子痫的有效性和安全性已有充分记录。在同一时期，海外使用了许多抗惊厥药物；然而，尚未找到理想的药物。最近，苯妥英钠被推荐作为硫酸镁的替代品；然而，关于其安全性和有效性的综合数据尚缺。文献中的证据表明，硫酸镁是先兆子痫-子痫的理想抗惊厥药物。
