Milne B
Department of Anaesthesia, Queen's University, Kingston, Ontario, Canada.
Med Hypotheses. 1996 Oct;47(4):333-5. doi: 10.1016/s0306-9877(96)90075-4.
Despite the relatively high incidence of essential hypertension and pregnancy-induced hypertension, the etiologies of these disorders remain enigmatic. A link between stretching of neural structures in the lower body and the induction of hypertension in these disorders is hypothesized. Hypertension has been documented in patients undergoing femoral and tibial lengthening procedures; in experimental models the stretching of lower extremity nerves appeared to be responsible for the increase in blood pressure with bone lengthening. The upright posture of humans puts an added strain on nerves and an increased pressure on lumbar disks may put increasing tension on the nerve roots. The resultant nerve stretch in pregnant women may be exacerbated by the hormone relaxin. A possible link between the stretching of neural structures and the genesis of essential hypertension or pre-eclampsia/eclampsia is hypothesized.
尽管原发性高血压和妊娠高血压的发病率相对较高，但这些疾病的病因仍然不明。有人推测，下半身神经结构的拉伸与这些疾病中高血压的诱发之间存在联系。接受股骨和胫骨延长手术的患者中已记录到高血压；在实验模型中，下肢神经的拉伸似乎是骨延长时血压升高的原因。人类的直立姿势会给神经增加额外的压力，腰椎间盘压力的增加可能会使神经根承受越来越大的张力。孕妇体内的激素松弛素可能会加剧由此导致的神经拉伸。有人推测，神经结构的拉伸与原发性高血压或先兆子痫/子痫的发生之间可能存在联系。
