May F E, Stewart R B, Cluff L E
Clin Pharmacol Ther. 1977 Sep;22(3):322-8. doi: 10.1002/cpt1977223322.
Effects of multiple drug administration on adverse drug reactions were studied in 10,518 patients hospitalized on a general medical service during a five-year period. Nine index drug groups, including analgesic, antacid, antiarrhythmic, antimicrobic, anticoagulant, antihypertensive, anti-inflammatory, diuretic, and sedative-tranquilizer drugs, were selected for study. The average number of adverse drug reactions for the anticoagulant and antihypertensive drug groups was higher (p less than 0.05) than for all other drug groups when classified by the number of drugs being taken concurrently (i.e., 0 to 5, 6 to 10, etc.). The rate of reaction for anticoagulant and antihypertensive drug groups was higher (p less than 0.001) than the rate for other drug groups studied. These data suggest a higher risk of adverse drug reactions for patients receiving multiple drugs. The increased risk may result from drug interactions.
在五年期间，对10518名在普通内科住院的患者进行了多种药物联合使用对药物不良反应影响的研究。研究选取了九个索引药物组，包括镇痛药、抗酸药、抗心律失常药、抗菌药、抗凝药、抗高血压药、抗炎药、利尿药和镇静 - 安定药。按同时服用药物的数量（即0至5种、6至10种等）分类时，抗凝药和抗高血压药组的药物不良反应平均数量高于（p小于0.05）所有其他药物组。抗凝药和抗高血压药组的反应率高于（p小于0.001）所研究的其他药物组。这些数据表明接受多种药物治疗的患者发生药物不良反应的风险更高。风险增加可能是由药物相互作用导致的。
