Fine R, McCullough B, Collins J F, Johanson W G
J Appl Physiol Respir Environ Exerc Physiol. 1979 Jul;47(1):138-44. doi: 10.1152/jappl.1979.47.1.138.
Static deflation air and saline pressure-volume (PV) curves were performed on five normal excised baboon lungs, four with radiation-induced upper lobe fibrosis, and two with diffuse bleomycin-induced fibrosis. Curves were compared visually and using half-inflation pressures (h). When plotted as percent of observed vital capacity vs. transpulmonary pressure, the radiation-associated curves were similar in shape to control curves. Also, h values were not significantly different between the two groups. The bleomycin-associated curves, however, were shifted rightward and exhibited increased h values. PV curves were correlated with connective tissue data. Elastin concentration was increased in the irradiated upper lobes through loss of associated constituents. Elastin accumulated in the lower lobes of the irradiated animals through compensatory growth and in the bleomycin-associated lungs through excessive production. Collagen followed a similar but less dramatic trend. We conclude connective tissue accumulation may not lead to rightward shifted PV curves if accumulation is present in relatively noninflatable lung units, or as part of compensatory lung growth.
对5个正常的离体狒狒肺、4个因辐射诱导上叶纤维化的肺以及2个因博来霉素诱导弥漫性纤维化的肺进行了静态放气空气和生理盐水压力-容积（PV）曲线测定。通过视觉和使用半充气压力（h）对曲线进行比较。当以观察到的肺活量百分比与跨肺压作图时，与辐射相关的曲线在形状上与对照曲线相似。此外，两组之间的h值没有显著差异。然而，与博来霉素相关的曲线向右移位且h值增加。PV曲线与结缔组织数据相关。通过相关成分的丧失，照射的上叶中弹性蛋白浓度增加。弹性蛋白通过代偿性生长在照射动物的下叶中蓄积，在与博来霉素相关的肺中通过过度产生而蓄积。胶原蛋白呈现类似但不太明显的趋势。我们得出结论，如果结缔组织蓄积存在于相对不易充气的肺单位中，或作为肺代偿性生长的一部分，则可能不会导致PV曲线向右移位。
