Tandon S K, Gaur J S
Clin Toxicol. 1977 Sep;11(2):257-64. doi: 10.3109/15563657708989838.
In an attempt to find more reliable therapeutic or preventive agents for industrial chromium poisoning, some structurally different metal binding agents were screened for their ability to mobilize chromium from liver, kidney, brain, and testes (in vivo) and their subcellular fractions (in vitro), together with the blood corpuscles of experimentally intoxicated animals. Ethylenedinitrilotetraacetic acid (EDTA) and diethylenetriamine pentaacetic acid (DTPA) were quite successful in vivo, while ascorbic acid and 3,4-dihydroxy-L-phenyl alanine (L-DOPA) were more effective in vitro. No relationship could be observed between the structure or the molecular weight of the various chelating agents examined and their ability to remove chromium from either the tissue or their subcellular fractions.
为了寻找更可靠的工业铬中毒治疗或预防药物，筛选了一些结构不同的金属结合剂，以研究它们从肝脏、肾脏、大脑和睾丸（体内）及其亚细胞部分（体外）以及实验性中毒动物的血细胞中动员铬的能力。乙二胺四乙酸（EDTA）和二乙烯三胺五乙酸（DTPA）在体内相当成功，而抗坏血酸和3,4-二羟基-L-苯丙氨酸（L-DOPA）在体外更有效。在所研究的各种螯合剂的结构或分子量与其从组织或其亚细胞部分去除铬的能力之间未观察到相关性。
