Muskat Y, Bukovsky I, Schneider D, Langer R
Department of Obstetrics and Gynecology, Assaf Harofe Medical Center, Zerifin, Israel.
J Urol. 1996 Dec;156(6):1989-90.
A prospective randomized double-blind study was done to evaluate the efficiency of transdermal scopolamine in the treatment of detrusor instability.
A total of 20 female patients with detrusor instability was assigned randomly into 2 groups of 10 each. The study group received 4 transdermal scopolamine dermal patches postauricularly, while in the control group placebo patches were applied. Both groups were similar regarding patient age, parity, duration of symptoms and previous anti-incontinence surgery.
The patients were reassessed after 14 days. Improvement in complaints of diurnal frequency (p < 0.05), nocturia (p < 0.005), urgency (p < 0.05) and urge incontinence (p < 0.05) was noted in the study group and not in the control group. A significantly (p < 0.05) less pressure increase on filling and a decreased volume at which pressure exceeded 15 cm. water (p < 0.05) were noted on cystometry in the study group only. No significant side effects were reported and no patient discontinued treatment.
Transdermal scopolamine was effective and safe in the treatment of female patients with detrusor instability.
进行一项前瞻性随机双盲研究，以评估透皮东莨菪碱治疗逼尿肌不稳定的疗效。
将20例逼尿肌不稳定的女性患者随机分为两组，每组10例。研究组于耳后贴4片透皮东莨菪碱皮肤贴片，而对照组贴安慰剂贴片。两组在患者年龄、产次、症状持续时间和既往抗尿失禁手术方面相似。
14天后对患者进行重新评估。研究组日间尿频（p<0.05）、夜尿症（p<0.005）、尿急（p<0.05）和急迫性尿失禁（p<0.05）症状有所改善，而对照组无改善。仅在研究组膀胱测压时发现充盈时压力升高明显降低（p<0.05），且压力超过15厘米水柱时的容量减小（p<0.05）。未报告明显副作用，也无患者停止治疗。
透皮东莨菪碱治疗女性逼尿肌不稳定有效且安全。
