Godfrey K M, Robinson S, Hales C N, Barker D J, Osmond C, Taylor K P
Medical Research Council Environmental Epidemiology Unit, (University of Southampton), Southampton General Hospital, UK.
Diabet Med. 1996 Oct;13(10):868-73. doi: 10.1002/(SICI)1096-9136(199610)13:10<868::AID-DIA261>3.0.CO;2-4.
As insulin is a major fetal growth hormone, we have related the mother's nutrient intakes (assessed by a food frequency questionnaire) and other influences associated with fetal growth to the baby's concentrations of insulin and its propeptides in umbilical cord plasma. Among 391 term babies studied, those whose mothers had high energy intakes in early pregnancy and low protein intakes in late pregnancy had lower cord plasma concentrations of 32-33 split proinsulin, insulin, and C-peptide. Concentrations of split proinsulin fell by 0.66 (95% Cl 0.29 to 1.03, p = 0.0006) log pmol l-1 for each log kcal increase in the mother's energy intake in early pregnancy and by 0.005 (95% Cl 0.000 to 0.010, p = 0.04) log pmol l-1 for each g decrease in protein intake in late pregnancy. Insulin and propeptide concentrations were however unrelated to the mother's height and body mass index, and to smoking during pregnancy. These observations parallel recent studies relating the same pattern of dietary intakes to impaired fetal and placental growth. Although dietary intakes assessed by food frequency questionnaires allow only cautious conclusions, our findings could have implications for the offspring's risk of Type 2 diabetes mellitus in adult life.
由于胰岛素是一种主要的胎儿生长激素，我们已将母亲的营养摄入量（通过食物频率问卷评估）以及与胎儿生长相关的其他影响因素，与婴儿脐带血血浆中胰岛素及其前体肽的浓度联系起来。在研究的391名足月儿中，那些母亲在孕早期能量摄入量高而在孕晚期蛋白质摄入量低的婴儿，其脐带血血浆中32 - 33裂解胰岛素原、胰岛素和C肽的浓度较低。母亲孕早期能量摄入量每增加1个对数千卡，裂解胰岛素原浓度下降0.66（95%可信区间0.29至1.03，p = 0.0006）对数皮摩尔/升；母亲孕晚期蛋白质摄入量每减少1克，裂解胰岛素原浓度下降0.005（95%可信区间0.000至0.010，p = 0.04）对数皮摩尔/升。然而，胰岛素和前体肽浓度与母亲的身高、体重指数以及孕期吸烟无关。这些观察结果与最近将相同饮食摄入模式与胎儿和胎盘生长受损相关联的研究一致。尽管通过食物频率问卷评估的饮食摄入量只能得出谨慎的结论，但我们的发现可能对后代成年后患2型糖尿病的风险有影响。
