Matsukawa T, Sugiyama Y, Mano T
Department of Autonomic and Behavioral Neurosciences, Nagoya University, Japan.
J Auton Nerv Syst. 1996 Sep 12;60(3):209-12. doi: 10.1016/0165-1838(96)00057-4.
To determine how the baroreflex control of sympathetic nerve activity is affected by aging, muscle sympathetic nerve activity (MSNA) from the tibial nerve was monitored using microneurography, and heart rate and blood pressure were recorded during the pressor or depressor responses to intravenous injections of phenylephrine or nitroglycerin in 39 healthy humans, aged 16 to 56 years. Although the baroreflex slope for heart rate showed attenuation with aging, the baroreflex slope for MSNA was not affected by aging. These data suggest preservation of the baroreflex control of sympathetic nerve activity despite attenuation of the baroreflex control of parasympathetic nerve activity by aging in humans.
为了确定压力反射对交感神经活动的控制如何受衰老影响，我们使用微神经ography监测了39名年龄在16至56岁之间的健康人的胫神经肌肉交感神经活动（MSNA），并在静脉注射去氧肾上腺素或硝酸甘油引起的升压或降压反应期间记录了心率和血压。尽管心率的压力反射斜率随衰老而衰减，但MSNA的压力反射斜率不受衰老影响。这些数据表明，尽管衰老会使副交感神经活动的压力反射控制减弱，但人类交感神经活动的压力反射控制仍得以保留。
