Matsukawa T, Sugiyama Y, Watanabe T, Kobayashi F, Mano T
Department of Autonomic Neuroscience, Research Institute of Environmental Medicine, Nagoya University, Japan.
J Auton Nerv Syst. 1998 Nov 10;73(2-3):182-5. doi: 10.1016/s0165-1838(98)00128-3.
To determine whether the baroreflex control of sympathetic nerve activity is attenuated in the elderly, muscle sympathetic nerve activity (MSNA) from the tibial nerve was monitored using microneurography, and heart rate and blood pressure were recorded during the depressor (phase II) or pressor (phase IV) period to Valsalva's maneuver in 10 younger subjects and 7 aged subjects. The baroreflex slope for heart rate showed attenuation in the aged subjects during the pressor phase but not during the depressor phase, the baroreflex slope for MSNA was also attenuated in the aged subjects during the pressor and tended to be attenuated during the depressor phases. These data suggest impaired baroreflex function for both heart rate and sympathetic nerve activity in the elderly.
为了确定老年人压力反射对交感神经活动的控制是否减弱，采用微神经ography监测10名年轻受试者和7名老年受试者胫神经的肌肉交感神经活动（MSNA），并在瓦尔萨尔瓦动作的降压期（II期）或升压期（IV期）记录心率和血压。老年受试者在升压期心率的压力反射斜率减弱，但在降压期未减弱，MSNA的压力反射斜率在老年受试者的升压期也减弱，在降压期有减弱趋势。这些数据表明老年人的心率和交感神经活动的压力反射功能受损。
