Crawford R I, Lawlor E R, Wadsworth L D, Prendiville J S
Division of Dermatology, British Columbia's Children's Hospital, Vancouver, Canada.
J Am Acad Dermatol. 1996 Nov;35(5 Pt 2):833-4. doi: 10.1016/s0190-9622(96)90096-1.
We describe a neonate with hemolytic disease of the newborn in whom a photosensitivity eruption developed during phototherapy for treatment of hyperbilirubinemia. Free erythrocyte protoporphyrin and zinc protoporphyrin levels were markedly elevated during the neonatal period. Porphyrin levels were normal at 19 weeks of age. The infant had residual skin atrophy and showed clinical and radiologic evidence of kernicterus. The pathogenesis of transient porphyrinemia associated with hemolytic disease of the newborn is unclear.
我们描述了一名患有新生儿溶血病的新生儿，其在接受光疗以治疗高胆红素血症期间出现了光敏感性皮疹。新生儿期游离红细胞原卟啉和锌原卟啉水平显著升高。19周龄时卟啉水平正常。该婴儿有皮肤萎缩残留，并显示出核黄疸的临床和影像学证据。与新生儿溶血病相关的短暂性卟啉血症的发病机制尚不清楚。
