染色质蛋白水解前后，小鼠DNA修复缺陷突变细胞系（SL3-147）中重离子诱导的DNA双链断裂的差异。
Differences in heavy-ion-induced DNA double-strand breaks in a mouse DNA repair-deficient mutant cell line (SL3-147) before and after chromatin proteolysis.
作者信息
Murakami M, Eguchi-Kasai K, Sato K, Minohara S, Yatagai F, Kanai T
机构信息
Division of Radiobiology and Biodosimetry, National Institute of Radiological Sciences, Chiba-shi, Japan.
出版信息
J Radiat Res. 1995 Dec;36(4):258-64. doi: 10.1269/jrr.36.258.
DNA double-strand breaks induced by X- or neon beam-irradiation in a DNA double-strand break-repair-deficient mutant cell line (SL3-147) were examined. The increase in the number of DNA double-strand breaks was dose depend after irradiation with X-rays and neon beams and was enhanced by chromatin-proteolysis treatment before irradiation. These results suggest that the induction of DNA double-strand breaks by ionizing radiation, including heavy-ions, is influenced by the chromatin structure.
研究了在DNA双链断裂修复缺陷型突变细胞系（SL3-147）中，X射线或氖离子束辐照诱导的DNA双链断裂情况。DNA双链断裂数量的增加在X射线和氖离子束辐照后呈剂量依赖性，并且在辐照前进行染色质蛋白水解处理后会增强。这些结果表明，包括重离子在内的电离辐射诱导的DNA双链断裂受到染色质结构的影响。
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