依托泊苷增加L1210小鼠白血病细胞中的脱氧胞苷激酶活性。
Increased deoxycytidine kinase activity by etoposide in L1210 murine leukemic cells.
作者信息
Ooi K, Ohkubo T, Higashigawa M, Kawasaki H, Sakurai M
机构信息
Department of Pharmacy, Yokkaichi Social Insurance Hospital, Mie, Japan.
出版信息
Biol Pharm Bull. 1996 Oct;19(10):1382-3. doi: 10.1248/bpb.19.1382.
Deoxycytidine kinase (dCK) is a rate-limiting enzyme for the activation of ara-C. It is responsible for the phosphorylation of ara-C which is widely used in the treatment of leukemia. We examined the effect of etoposide on dCK in L1210 cells and found that incubation with 10 microM etoposide for 1 h increased dCK activity to 170% of the control. This effect of etoposide on dCK activity was concentration-dependent up to at least 100 microM of the substance.
脱氧胞苷激酶（dCK）是阿糖胞苷激活过程中的限速酶。它负责阿糖胞苷的磷酸化，阿糖胞苷广泛用于白血病治疗。我们检测了依托泊苷对L1210细胞中dCK的影响，发现用10微摩尔/升依托泊苷孵育1小时后，dCK活性增加至对照的170%。依托泊苷对dCK活性的这种影响在该物质浓度至少达到100微摩尔/升时呈浓度依赖性。
Zotero 插件