Mochida-Nishimura K, Tokunaga T
Department of Bacterial and Blood Products, National Institute of Health, Tokyo, Japan.
Immunopharmacology. 1996 Oct;35(1):65-70. doi: 10.1016/0162-3109(96)00116-6.
Effects of the immunosuppressive agent, 15-deoxyspergualin (DSG) on hemopoiesis and thymocyte populations were examined in mice. The numbers of bone marrow (BM) cells decreased after the administration of DSG for up to 8 days, and the extent of this decrease was correlated inversely to the time of administration. Conversely, the BM cells of DSG-treated mice had enhanced proliferative responses in vitro and in viv. Deoxymethylspergualin, DSG analogue, directly suppressed the proliferation of BM cells in vitro in a time and dose-dependent manner. Total thymocyte counts decreased following the administration of DSG. The numbers of immature, peanut agglutinin-binding (PNA+) thymocytes decreased notably. Minor changes were observed in the mature thymocytes and spleen cells of DSG-treated mice.
在小鼠中检测了免疫抑制剂15-去氧精胍菌素（DSG）对造血作用和胸腺细胞群体的影响。给予DSG长达8天后，骨髓（BM）细胞数量减少，且这种减少的程度与给药时间呈负相关。相反，经DSG处理的小鼠的BM细胞在体外和体内的增殖反应增强。DSG类似物脱氧甲基精胍菌素在体外以时间和剂量依赖性方式直接抑制BM细胞的增殖。给予DSG后，胸腺细胞总数减少。未成熟的、花生凝集素结合（PNA +）胸腺细胞数量显著减少。在经DSG处理的小鼠的成熟胸腺细胞和脾细胞中观察到轻微变化。
