催乳素调节由某些葡萄球菌和链球菌毒素刺激的小鼠脾细胞释放白细胞介素-1α、干扰素-γ和白细胞介素-4。
Prolactin regulates IL-1 alpha, IFN-gamma and IL-4 release from mouse splenocytes stimulated with some staphylococcal and streptococcal toxins.
作者信息
Scarfogliero P, Vitiello M, Galdiero M, Brancaccio F, Sommese L
机构信息
Istituto di Microbiologia, Facoltà di Medicina e Chirurgia, Seconda Università degli Studi di Napoli, Italy.
出版信息
New Microbiol. 1996 Oct;19(4):301-8.
This study investigates changes in IL-1 alpha, IFN-gamma and IL-4 from mouse splenocytes stimulated with Staphylococcal Protein A (PA), or Toxic Shock Syndrome Toxin-1 (TSST-1), or Streptococcal lysin S (SLS) after exposure to Prolactin (PRL). In the presence of PRL, IL-1 alpha and IFN-gamma induction by PA-stimulated splenocytes was reduced by 74% and 25% respectively. On the other hand, IL-4 release was enormously increased. The ability of TSST-1 to induce IFN-gamma release was decreased by 32% after PRL. IL-1 alpha and IL-4 was unchanged compared to controls. In the presence of PRL, IFN-gamma release from splenocytes stimulated with SLS, was increased by 60%, while no changes were shown in IL-1 alpha and IL-4 release.
本研究调查了暴露于催乳素（PRL）后，用葡萄球菌蛋白A（PA）、中毒性休克综合征毒素-1（TSST-1）或链球菌溶素S（SLS）刺激的小鼠脾细胞中白细胞介素-1α（IL-1α）、γ-干扰素（IFN-γ）和白细胞介素-4（IL-4）的变化。在PRL存在的情况下，PA刺激的脾细胞诱导的IL-1α和IFN-γ分别降低了74%和25%。另一方面，IL-4的释放大幅增加。PRL作用后，TSST-1诱导IFN-γ释放的能力降低了32%。与对照组相比，IL-1α和IL-4没有变化。在PRL存在的情况下，SLS刺激的脾细胞释放的IFN-γ增加了60%，而IL-1α和IL-4的释放没有变化。
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