Ogino Y, Toriumi M, Tanaka K
Third Department of Medicine, Teikyo University School of Medicine.
Nihon Rinsho. 1996 Oct;54(10):2667-71.
Endocrine disorders associated with diabetes mellitus are described. When blood glucose control deteriorates, observed endocrine abnormalities are as follows. 1) Blood GH levels increase. This elevation is small but enough to disturb insulin secretion and glucose metabolism. Plama insulin-like growth factor-1 levels decrease in spite of their strong relation with diabetic retinopathy. 2) Blood thyroid hormones show the similarity with low T3 syndrome. 3) Hyporeninemic hypoaldosteronism occurs especially with patients who have hypertension or moderate diabetic complications. 4) Plasma pancreatic glucagon levels are elevated. Amino acids induce hypersecretion but hypoglycemia fails to response normally. Glucose administration shows impaired inhibition or paradoxical hypersecretion. 5) Other plasma levels of pancreatic hormones such as gastrin, secretin, motilin and somatostatin are usually elevated.
描述了与糖尿病相关的内分泌紊乱。当血糖控制恶化时，观察到的内分泌异常如下：1）血液生长激素水平升高。这种升高幅度较小，但足以干扰胰岛素分泌和葡萄糖代谢。尽管血浆胰岛素样生长因子-1水平与糖尿病视网膜病变密切相关，但仍会降低。2）血液甲状腺激素表现出与低T3综合征相似的情况。3）低肾素性低醛固酮血症尤其发生在患有高血压或中度糖尿病并发症的患者中。4）血浆胰高血糖素水平升高。氨基酸诱导分泌过多，但低血糖时不能正常反应。给予葡萄糖显示抑制受损或反常性分泌过多。5）其他血浆胰腺激素水平，如胃泌素、促胰液素、胃动素和生长抑素通常会升高。
