Kiyohara Y, Fujishima M
Second Department of Internal Medicine, Faculty of Medicine, Kyushu University.
Nihon Rinsho. 1996 Oct;54(10):2755-60.
To elucidate the prevalence and relevant factors of glucose intolerance and its effect on the development of cardiovascular disease in the current general Japanese population, we conducted a cross-sectional survey of glucose intolerance by a 75-g oral glucose tolerance test in 2,490 subjects aged 40-79 years old selected from a Japanese community, Hisayama, in 1988, and followed them for 5 years. The prevalence of diabetes (NIDDM) was 13% for men and 9% for women, and that of impaired glucose tolerance (IGT) was 20% and 19%, respectively. Both IGT and NIDDM were significantly associated with factors related to insulin resistance including the sum of insulin concentrations. In addition, subjects with IGT and NIDDM had a significantly higher risk of occurrence of cardiovascular disease (stroke and coronary heart disease) than did those with normal glucose tolerance.
为了阐明目前日本普通人群中葡萄糖不耐受的患病率、相关因素及其对心血管疾病发展的影响，我们于1988年对从日本久山社区选取的2490名40 - 79岁的受试者进行了一项横断面调查，通过75克口服葡萄糖耐量试验检测葡萄糖不耐受情况，并对他们进行了5年的随访。男性糖尿病（非胰岛素依赖型糖尿病）患病率为13%，女性为9%，葡萄糖耐量受损（IGT）患病率分别为20%和19%。IGT和非胰岛素依赖型糖尿病均与包括胰岛素浓度总和在内的胰岛素抵抗相关因素显著相关。此外，与葡萄糖耐量正常的受试者相比，IGT和非胰岛素依赖型糖尿病患者发生心血管疾病（中风和冠心病）的风险显著更高。
