Saito M, Morishita E, Asakura H, Jokaji H, Uotani C, Kumabashiri I, Yamazaki M, Aoshima K, Matsuda T
Third Department of Internal Medicine, Kanazawa University School of Medicine.
Rinsho Ketsueki. 1996 Sep;37(9):794-8.
We measured plasma levels of tissue factor (TF), total tissue factor pathway inhibitor (TFPI) and free TFPI antigen in patients with diabetes mellitus (DM), hyperlipidemia and disseminated intravascular coagulation (DIC). The mean TF, total TFPI and free TFPI antigen concentrations were significantly higher in patients with DM than in controls and the plasma TF concentration was significantly higher in patients with retinopathy or nephropathy than in DM with no complications. The mean TF, total TFPI and free TFPI antigen concentrations were significantly higher in patients with hyperlipidemia than in controls. There was a significant positive correlation between levels of total TFPI and total cholesterol. In patients with hyperlipidemia, the level of total TFPI was significantly decreased compared to base line level by cholesterol lowering drug, however, free TFPI concentration did not change by cholesterol lowering drug. The TF and total TFPI concentrations were significantly higher in patients with DIC than in controls.
我们测定了糖尿病（DM）、高脂血症和弥散性血管内凝血（DIC）患者血浆中组织因子（TF）、总组织因子途径抑制物（TFPI）和游离TFPI抗原的水平。DM患者的平均TF、总TFPI和游离TFPI抗原浓度显著高于对照组，视网膜病变或肾病患者的血浆TF浓度显著高于无并发症的DM患者。高脂血症患者的平均TF、总TFPI和游离TFPI抗原浓度显著高于对照组。总TFPI水平与总胆固醇之间存在显著正相关。在高脂血症患者中，降胆固醇药物使总TFPI水平较基线水平显著降低，然而，游离TFPI浓度并未因降胆固醇药物而改变。DIC患者的TF和总TFPI浓度显著高于对照组。
