Eldridge J C
Endocr Res Commun. 1977;4(2):135-46. doi: 10.3109/07435807709073918.
Electrochemical stimulation (ECS) of the medial preoptic area (MPOA) in the male rat produced an attenuated release of pituitary FSH and LH analogous to that induced in the female during Diestrus I and II. However, orchidectomy followed by estradiol-benzoate replacement resulted in a massive release of LH following ECS; FSH was again minimally responsive. Electrode implantation without ECS (sham control) was without effect upon either gonadotropin. Results indicate that the male rat can be provoked to a massive release of LH by ECS when an estrogen environment is provided; androgens appear to interfere. We also conclude that the MPOA connection for releasing-hormore secretion is intact in the male rat, and is sensitive to an external stimulus.
对雄性大鼠内侧视前区（MPOA）进行电化学刺激（ECS），会使垂体促卵泡激素（FSH）和促黄体生成素（LH）的释放减弱，这类似于在雌性大鼠动情间期I和II期间所诱导的情况。然而，切除睾丸后用苯甲酸雌二醇替代，会导致ECS后LH大量释放；FSH再次反应极小。未进行ECS的电极植入（假对照）对两种促性腺激素均无影响。结果表明，当提供雌激素环境时，ECS可促使雄性大鼠大量释放LH；雄激素似乎起干扰作用。我们还得出结论，雄性大鼠中用于释放激素分泌的MPOA连接是完整的，并且对外部刺激敏感。
