Takeuchi K, Ukai K, Lee H S, Majima Y, Sakakura Y
Department of Otorhinolaryngology, Mie University School of Medicine, Tsu, Japan.
Laryngoscope. 1996 Nov;106(11):1419-23. doi: 10.1097/00005537-199611000-00022.
To explore the dynamics of the cellular response to natural allergen exposure, the authors of this study performed quantitative cytology in both the nasal secretions and nasal scrapings of 16 normal control subjects and 23 Japanese cedar pollinosis patients before and during the pollen season. In nasal scrapings, the number of metachromatic cells increased significantly during the pollen season, although there was no significant difference between the normal subjects and the preseason pollinosis patients. The cell differential count in the patients with pollinosis showed that lymphocytes were predominant in scrapings; however, the majority of inflammatory cells in the nasal secretions were neutrophils before the season and eosinophils during the season. The study findings suggest that the appearance of metachromatic cells in nasal scrapings is specific to the pollen exposure and that the cytology in nasal secretions is significantly different from that in nasal scrapings.
为探究细胞对自然过敏原暴露的反应动态，本研究的作者在花粉季节之前和期间，对16名正常对照受试者以及23名日本雪松花粉症患者的鼻分泌物和鼻刮片进行了定量细胞学检查。在鼻刮片中，异染细胞的数量在花粉季节显著增加，尽管正常受试者与花粉症前期患者之间无显著差异。花粉症患者的细胞分类计数显示，刮片中淋巴细胞占主导；然而，鼻分泌物中的大多数炎症细胞在季节前为中性粒细胞，在季节期间为嗜酸性粒细胞。研究结果表明，鼻刮片中异染细胞的出现是花粉暴露所特有的，并且鼻分泌物中的细胞学与鼻刮片中的显著不同。
