Penneys N S
Department of Dermatology, Saint Louis University School of Medicine, MO 63104, USA.
Br J Dermatol. 1996 Oct;135(4):592-4.
Focal adhesion kinase is a protein-tyrosine kinase that is found in cellular contact sites and is phosphorylated in response to cell attachment. It is possible that the immunohistochemical detection of this enzyme might be increased in keratinocytes involved in an acantholytic process. Normal skin, pemphigus vulgaris and foliaceus, Darier's disease, Hailey--Hailey disease, warty dyskeratoma, Grover's disease and spongiotic dermatitis were assayed for the immunohistochemical expression of focal adhesion kinase. Focal adhesion kinase was not observed in normal epidermis. This antigen was observed in keratinocytes adjacent to acantholytic spaces and in acantholytic cells in pemphigus vulgaris and foliaceus. Focal adhesion kinase was not detected in keratinocytes involved in focal acantholytic dyskeratoses such as Darier's disease, Grover's disease and warty dyskeratoma but was weakly detected in Hailey--Hailey disease. One consequence of immunologically mediated acantholysis is the upregulation of focal adhesion kinase possibly as a component of biochemical pathways that reconstruct the process of adhesion or respond to the process of acantholysis.
粘着斑激酶是一种蛋白酪氨酸激酶，存在于细胞接触部位，在细胞附着时会发生磷酸化。在棘层松解过程中的角质形成细胞中，这种酶的免疫组织化学检测结果可能会增加。对正常皮肤、寻常型天疱疮、落叶型天疱疮、达里埃病、黑利-黑利病、疣状角化不良瘤、格罗弗病和海绵状皮炎进行了粘着斑激酶的免疫组织化学表达检测。在正常表皮中未观察到粘着斑激酶。在寻常型天疱疮和落叶型天疱疮中，在棘层松解间隙附近的角质形成细胞和棘层松解细胞中观察到了这种抗原。在达里埃病、格罗弗病和疣状角化不良瘤等局灶性棘层松解性角化不良所涉及的角质形成细胞中未检测到粘着斑激酶，但在黑利-黑利病中检测到弱阳性。免疫介导的棘层松解的一个结果可能是粘着斑激酶上调，这可能是重建粘着过程或对棘层松解过程作出反应的生化途径的一个组成部分。
