Laeng P, Molthagen M, Yu E G, Bartsch U
Department of Neurobiology, Swiss Federal Institute of Technology, Zürich, Switzerland.
Glia. 1996 Nov;18(3):200-10. doi: 10.1002/(SICI)1098-1136(199611)18:3<200::AID-GLIA4>3.0.CO;2-2.
In most mammals, retinal ganglion cell axons are unmyelinated in the retina. The same axons become myelinated in the optic nerve. Various studies suggest that retinal ganglion cell axons are also in principle, myelination competent intraretinally and that non-neuronal factors at the retinal end of the optic nerve prevent the migration of oligodendrocyte progenitor cells into the retina. To test this hypothesis directly, we injected oligodendrocyte progenitor cells into the retina of young postnatal rats. We observed massive myelination of ganglion cell axons in the retina 1 month after cell transplantation. Electron microscopic analysis revealed that intraretinal segments of ganglion cell axons were surrounded by central nervous system myelin sheaths with a normal morphology. Our results thus provide direct evidence for the myelination competence of the intraretinal part of rat retinal ganglion cell axons.
在大多数哺乳动物中，视网膜神经节细胞的轴突在视网膜内是无髓鞘的。同样的轴突在视神经中会形成髓鞘。各种研究表明，视网膜神经节细胞的轴突原则上在视网膜内也具备髓鞘形成能力，并且视神经视网膜端的非神经元因素会阻止少突胶质细胞祖细胞迁移到视网膜中。为了直接验证这一假设，我们将少突胶质细胞祖细胞注入新生幼鼠的视网膜。细胞移植1个月后，我们观察到视网膜中神经节细胞轴突出现大量髓鞘形成。电子显微镜分析显示，神经节细胞轴突的视网膜内节段被形态正常的中枢神经系统髓鞘所包围。因此，我们的结果为大鼠视网膜神经节细胞轴突的视网膜内部分具备髓鞘形成能力提供了直接证据。
