Assouline G, Leibson V, Danon A
Eur J Pharmacol. 1977 Aug 1;44(3):271-3. doi: 10.1016/0014-2999(77)90073-5.
A whole-cell preparation of rat stomach put out appreciable amounts of immunoassayable PGE. Buffers made hypertonic with either sodium chloride or mannitol effected several-fold increases in PGE output, while a comparable osmotic concentration of urea seemed to produce much less stimulation. Enhancement of PGE output by saline--hypertonic buffers was concentration-dependent. It is suggested that the osmolarity of the gastric contents may play a role in regulating gastric PG biosynthesis.
大鼠胃的全细胞制剂可释放出相当数量的可通过免疫测定的前列腺素E（PGE）。用氯化钠或甘露醇使缓冲液变为高渗，可使PGE的释放量增加几倍，而渗透压相当的尿素似乎产生的刺激要小得多。盐水高渗缓冲液对PGE释放的增强作用呈浓度依赖性。提示胃内容物的渗透压可能在调节胃前列腺素生物合成中起作用。
