Kusalic M, Engelsmann F
Department of Psychiatry, McGill University, Montreal, Que., Canada.
Neuropsychobiology. 1996;34(3):113-6. doi: 10.1159/000119301.
The renal function was assessed in 51 bipolar patients on multiple-dosage lithium maintenance therapy from 1 to 22 years, after placing them on single (HS) dosage for 12-18 months. Serum lithium levels were maintained constant at a level of 0.8 mg/l. The patients were divided into three groups according to duration of previous multiple doses (b.i.d.-q.i.d.) Li therapy; less than 5 years; 5-10 years; 10-22 years. The improvement in water handling occurred only in the previously shortest multiple-dosage-treated patients and the duration of previous multiple dosage negatively influenced water handling; however, all laboratory analyses remained within normal limits. None of the patients showed clinical worsening or had an affective episode. The separate analyses showed associated gender differences in urinary volume, serum creatinine, and creatinine clearance values. Our findings confirmed the beneficial renal reaction to single-dose posology, as well the female sensitivity to Li therapy in general, and especially with concomitant antipsychotic medication.
对51例接受多剂量锂盐维持治疗1至22年的双相情感障碍患者进行肾功能评估，此前他们接受单剂量（HS）治疗12至18个月。血清锂水平维持在0.8 mg/l的恒定水平。根据先前多剂量（每日两次至每日四次）锂盐治疗的持续时间，将患者分为三组：少于5年；5至10年；10至22年。仅在先前接受多剂量治疗时间最短的患者中出现了水代谢处理能力的改善，而先前多剂量治疗的持续时间对水代谢处理产生了负面影响；然而，所有实验室分析结果均保持在正常范围内。没有患者出现临床病情恶化或情感发作。单独分析显示，在尿量、血清肌酐和肌酐清除率值方面存在性别差异。我们的研究结果证实了单剂量给药方案对肾脏有益的反应，以及女性总体上对锂盐治疗的敏感性，尤其是在同时使用抗精神病药物的情况下。
