Sabbatini M, Vega J A, Amenta F
Sezione di Anatomia Umana, Università di Camerino, Italy.
Neurosci Lett. 1996 Oct 18;217(2-3):85-8.
Circulation to the brain is affected by hypertension. Hypertension-dependent cerebrovascular changes were documented primarily in brain pial arteries, whereas no information is so far available concerning changes of peripheral nerve vascularization in hypertension. This study was designed to assess the occurrence of structural changes of interfascicular and intrafascicular arteries supplying peripheral nerves (the so called vasa nervorum) in spontaneously hypertensive rats (SHR). The investigation was performed in 8-month-old SHR, by using standard microanatomical techniques associated with quantitative image analysis. In SHR a significant increase of systolic pressure values accompanied by thickening of the arterial wall, narrowing of the lumen and increase of the wall-to-lumen ratio were observed in comparison with age-matched normotensive Wistar-Kyoto rats. Hypertension-related structural changes involved primarily interfascicular arteries and to a lesser extent intrafascicular arteries. These findings indicate that similarly as documented for cerebral arteries, the vascular supply to peripheral nerves is impaired in hypertension. Structural changes of interfascicular and intrafascicular arteries of SHR could lead to ischemia of peripheral nerves. Further work is in progress to evaluate the functional relevance of hypertensive changes to peripheral nerve vasculature.
高血压会影响脑部血液循环。高血压相关的脑血管变化主要记录在软脑膜动脉中，而目前尚无关于高血压患者周围神经血管化变化的信息。本研究旨在评估自发性高血压大鼠（SHR）中供应周围神经的束间动脉和束内动脉（即所谓的神经滋养血管）结构变化的发生情况。通过使用与定量图像分析相关的标准显微解剖技术，对8月龄的SHR进行了研究。与年龄匹配的正常血压Wistar-Kyoto大鼠相比，SHR的收缩压值显著升高，同时伴有动脉壁增厚、管腔狭窄和壁腔比增加。高血压相关的结构变化主要涉及束间动脉，束内动脉受影响程度较小。这些发现表明，与脑动脉的情况类似，高血压会损害周围神经的血管供应。SHR束间动脉和束内动脉的结构变化可能导致周围神经缺血。目前正在进一步开展工作，以评估高血压变化对周围神经血管系统的功能相关性。
