Fedrizzi E, Inverno M, Bruzzone M G, Botteon G, Saletti V, Farinotti M
Department of Developmental Neurology, Istituto Neurologico Nazionale C. Besta, Milan, Italy.
Pediatr Neurol. 1996 Oct;15(3):207-12. doi: 10.1016/s0887-8994(96)00174-9.
The aim of this study is to further clarify the relation between the pattern of cognitive impairment in spastic diplegic children born preterm and MRI features of cerebral lesions. The cognitive profile by Wechsler Scale of a sample of 30 children aged 6 years, 8 months to 14 years, 7 months was assessed, and the correlations between the Full Scale, Verbal, and Performance IQ and periventricular leukomalacia features on MRI were investigated. A significant difference was observed between the mean Verbal and Performance IQ, indicating a specific failure in the visuoperceptual functions of spastic diplegic children born preterm. Periventricular leukomalacia was detected in all children. The severity of ventricular dilatation, the degree and extent of white matter reduction, optic radiation involvement, and the thinning of the posterior corpus callosum correlated significantly with the Full Scale and Performance IQ: no correlation was observed between the Verbal IQ and any of the MRI features analyzed. In spastic diplegic children, an MRI examination between the ages of 1 and 2 years may be helpful in predicting a specific neuropsychological pattern of dysfunction and in defining an early intervention program.
本研究的目的是进一步阐明早产痉挛型双瘫儿童认知障碍模式与脑损伤的MRI特征之间的关系。评估了30名年龄在6岁8个月至14岁7个月的儿童样本通过韦氏智力量表得出的认知概况，并研究了全量表、言语和操作智商与MRI上脑室周围白质软化特征之间的相关性。观察到言语和操作智商均值之间存在显著差异，表明早产痉挛型双瘫儿童在视觉感知功能方面存在特定缺陷。所有儿童均检测到脑室周围白质软化。脑室扩张的严重程度、白质减少的程度和范围、视辐射受累情况以及胼胝体后部变薄与全量表和操作智商显著相关：未观察到言语智商与所分析的任何MRI特征之间存在相关性。对于痉挛型双瘫儿童，1至2岁时进行MRI检查可能有助于预测特定的神经心理功能障碍模式，并确定早期干预方案。
