Maas M I, Hopman W P, Katan M B, Jansen J B
Department of Gastroenterology & Hepatology, University Hospital of Nijmegen St. Radboud, The Netherlands.
Regul Pept. 1996 Oct 22;66(3):203-10. doi: 10.1016/S0167-0115(96)00111-5.
Long-chain triglycerides inhibit gastric acid secretion, but the effect of medium-chain triglycerides in humans is unknown. We compared the effects of intraduodenally perfused saline, medium-chain and long-chain triglycerides on gastrin-stimulated gastric acid secretion and cholecystokinin release. Eight healthy male volunteers participated in this study. Gastrin-stimulated gastric acid output was 9.4 +/- 1.1 mmol/30 min during saline perfusion. It was suppressed by medium-chain triglycerides by 43 +/- 9% (P = 0.04 vs. saline) and by long-chain triglycerides by 74 +/- 6% (P = 0.0003 vs. saline). Thus medium-chain triglycerides inhibited gastrin-stimulated gastric acid secretion but less so than long-chain triglycerides. When compared to saline perfusion (73 +/- 6 pM x 30 min) integrated plasma cholecystokinin concentrations were significantly elevated by long-chain triglycerides (96 +/- 5 pM x 30 min, P < 0.004) but not by medium-chain triglycerides perfusion (65 +/- 7 pM x 30 min). We also investigated the role of cholecystokinin infusion on gastrin stimulated gastric acid secretion. Higher concentrations (191.4 +/- 4.5 pM x 30 min) of CCK than released in the long-chain triglycerides perfusion experiment, did not suppress gastric acid secretion. Thus, circulating cholecystokinin appears not responsible for the inhibition of gastrin-stimulated gastric acid secretion by dietary fat.
长链甘油三酯可抑制胃酸分泌，但中链甘油三酯对人体的作用尚不清楚。我们比较了十二指肠灌注生理盐水、中链和长链甘油三酯对胃泌素刺激的胃酸分泌及胆囊收缩素释放的影响。8名健康男性志愿者参与了本研究。生理盐水灌注期间，胃泌素刺激的胃酸分泌量为9.4±1.1 mmol/30分钟。中链甘油三酯使其降低了43±9%（与生理盐水相比，P = 0.04），长链甘油三酯使其降低了74±6%（与生理盐水相比，P = 0.0003）。因此，中链甘油三酯可抑制胃泌素刺激的胃酸分泌，但作用程度低于长链甘油三酯。与生理盐水灌注（73±6 pM×30分钟）相比，长链甘油三酯灌注后血浆胆囊收缩素的综合浓度显著升高（96±5 pM×30分钟，P < 0.004），而中链甘油三酯灌注后则无明显变化（65±7 pM×30分钟）。我们还研究了输注胆囊收缩素对胃泌素刺激的胃酸分泌的作用。与长链甘油三酯灌注实验中释放的胆囊收缩素浓度相比，更高浓度（191.4±4.5 pM×30分钟）的胆囊收缩素并未抑制胃酸分泌。因此，循环中的胆囊收缩素似乎并非膳食脂肪抑制胃泌素刺激的胃酸分泌的原因。
