Ekström J, Ekman R, Tobin G
Department of Pharmacology, University of Göteborg, Sweden.
Regul Pept. 1996 Oct 22;66(3):211-2. doi: 10.1016/S0167-0115(96)00091-2.
Phentolamine and propranolol (2 mg/kg i.p. of each) were administered to rats to be fed hard chow over a period of 80 min and to their fasting controls. The pharmacological elimination of the adrenoceptor mediated secretory drive on the parotid gland cells during feeding did not affect the gland content of the peptides substance P and vasoactive intestinal peptide localized to parasympathetic nerve fibres of the gland and thought to transmit secretory impulses. This is in contrast to the previously demonstrated effect of elimination of the parasympathetic acetylcholine-evoked secretion following administration of atropine, which resulted in reduced gland contents of these peptides.
将酚妥拉明和普萘洛尔（各2毫克/千克腹腔注射）分别给予喂食硬饲料80分钟的大鼠及其禁食对照组。进食期间，肾上腺受体介导的腮腺细胞分泌驱动力的药理消除，并未影响腮腺中定位在该腺体副交感神经纤维上、被认为传递分泌冲动的P物质和血管活性肠肽这两种肽的腺体含量。这与先前证明的给予阿托品后消除副交感神经乙酰胆碱诱发的分泌所产生的效果形成对比，后者导致这些肽的腺体含量减少。
