Cohlen B J, Stigter R H, Derks J B, Mulder E J, Visser G H
Department of Obstetrics and Gynecology, University Hospital, Utrecht, The Netherlands.
Ultrasound Obstet Gynecol. 1996 Oct;8(4):252-5. doi: 10.1046/j.1469-0705.1996.08040252.x.
Maternal betamethasone administration causes a transient but considerable reduction in fetal body and breathing movements and in fetal heart rate variation. The aim of the present prospective study was to investigate whether there is evidence of circulatory changes in fetal, placental or uterine arteries, consistent with hypoxemia. Eighteen women at risk for preterm delivery received betamethasone to enhance fetal lung maturation. Doppler studies were performed before treatment, and 24 and 72 h after the second dose of betamethasone. Blood flow velocity waveforms were obtained from both uterine arteries, umbilical arteries, fetal descending aorta, fetal renal artery, and fetal cerebral arteries. No significant changes occurred in the pulsatility index of any of these blood vessels, suggesting that the transient reduction in fetal heart rate variation and fetal body and breathing movements following maternal betamethasone administration is not mediated through fetal hypoxemia.
母体使用倍他米松会导致胎儿身体活动、呼吸运动以及胎儿心率变异性出现短暂但显著的降低。本前瞻性研究的目的是调查是否有证据表明胎儿、胎盘或子宫动脉存在与低氧血症相符的循环变化。18名有早产风险的妇女接受了倍他米松治疗以促进胎儿肺成熟。在治疗前以及第二剂倍他米松给药后24小时和72小时进行了多普勒研究。从双侧子宫动脉、脐动脉、胎儿降主动脉、胎儿肾动脉和胎儿脑动脉获取血流速度波形。这些血管的搏动指数均未发生显著变化，这表明母体使用倍他米松后胎儿心率变异性以及胎儿身体活动和呼吸运动的短暂降低并非由胎儿低氧血症介导。
