Morin D, Valdez R, Lichtensteiger C, Paul A, DiPietro J, Guerino F
Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana 61801, USA.
Vet Parasitol. 1996 Oct 15;65(1-2):75-81. doi: 10.1016/0304-4017(96)00945-4.
The efficacy of 0.5% moxidectin pour-on at two dosages was evaluated in 30 cattle with naturally acquired gastrointestinal nematode infections. The cattle were ranked according to pretreatment fecal egg counts and body weights, and were randomly assigned from replicates to three treatment groups. The mean number of trichostrongyle eggs in pretreatment fecal samples did not differ among the groups. Groups I and II received 0.5% moxidectin pour-on at dosages of 0.25 mg moxidectin per kg body weight and 0.5 mg moxidectin per kg body weight, respectively, and Group III cattle received moxidectin-free vehicle (control cattle). The cattle were euthanized by complete replicate 14 or 15 days posttreatment for recovery of nematodes and examination of the pour-on sites. Treatment with moxidectin was associated with a significant reduction in fecal trichostrongyle egg counts compared with the control cattle; efficacy was 99.7% and > 99.9% for cattle in Groups I and II, respectively. Eleven species of adult nematodes (Haemonchus contortus, Haemonchus placei, Ostertagia ostertagi, Trichostrongylus axei, Trichostrongylus colubriformis, Bunostomum phlebotomum, Cooperia oncophora, Cooperia punctata, Nematodirus helvetianus, Oesophagostomum radiatum and Trichuris ovis) and 4th stage larvae of Ostertagia spp. and Trichostrongylus spp. were present in sufficient numbers in control cattle to evaluate the efficacy of moxidectin 0.5% pour-on. In all cases, treatment was associated with a significant reduction in the number of nematodes recovered at necropsy, with the efficacy of both dosages exceeding 99.9%. There were no significant differences in mean worm burdens or fecal egg counts between the two treated groups, and no adverse reactions were observed.
在30头自然感染胃肠道线虫的牛身上评估了两种剂量的0.5%莫昔克丁浇泼剂的疗效。根据预处理粪便虫卵计数和体重对牛进行排名，并从重复样本中随机分配到三个治疗组。预处理粪便样本中毛圆线虫卵的平均数量在各组之间没有差异。第一组和第二组分别接受剂量为每千克体重0.25毫克莫昔克丁和每千克体重0.5毫克莫昔克丁的0.5%莫昔克丁浇泼剂，第三组牛接受不含莫昔克丁的赋形剂（对照牛）。在治疗后14或15天，通过完全重复对牛实施安乐死，以回收线虫并检查浇泼部位。与对照牛相比，莫昔克丁治疗使粪便中毛圆线虫卵计数显著减少；第一组和第二组牛的疗效分别为99.7%和>99.9%。对照牛体内存在11种成年线虫（捻转血矛线虫、长刺血矛线虫、奥斯特他线虫、斧形毛圆线虫、蛇形毛圆线虫、牛仰口线虫、牛库珀线虫、点状库珀线虫、瑞士细颈线虫、辐射食道口线虫和绵羊鞭虫）以及奥斯特他属和毛圆属的第四期幼虫，数量足以评估0.5%莫昔克丁浇泼剂的疗效。在所有情况下，治疗均使尸检时回收的线虫数量显著减少，两种剂量疗效均超过99.9%。两个治疗组之间的平均虫负荷或粪便虫卵计数没有显著差异，也未观察到不良反应。
