Morini S, Pannarale L, Braidotti P, Marinozzi A, Gaudio E
Institute of Anatomy, State University of Rome, La Sapienza, Italy.
Ital J Anat Embryol. 1996 Jan-Mar;101(1):29-43.
Several pathogenetical and clinical interpretation of osteoarthritic modifications are given in the literature. In this work we tried to compare in humans macroscopic, structural and ultrastructural observations on eight osteoarthritic with four femural heads from control patients. The sample for Light Microscopy and Scanning Electron Microscopy observations came from selected regions of the femural head, which included both cartilage and bone tissue of loaded and unloaded regions. The cartilage showed superficial lesions, such as erosions and fissures, and deep lesions that included matrix alterations and chondrocyte proliferation. In relation to the thickening of the subchondral bone we noticed an irregular bone-cartilage surface with signs of bone tissue proliferation. The trabeculae appeared thickened in loaded zones and rarefied in unloaded ones. Cavities were sometimes present at different depths in cancellous bone. Our observations allow us to conclude that cartilage lesions are precocious, diffusely located and relatively independent of the considered zone of the femural head, while bone tissue alterations seem evenly sited and chronologically subsequent. The cavities in the cancellous bone could produce load modifications and consequent bone deformity.
文献中给出了骨关节炎改变的几种病理和临床解释。在这项研究中，我们试图比较人类中八例骨关节炎患者与四例对照患者股骨头的宏观、结构和超微结构观察结果。用于光学显微镜和扫描电子显微镜观察的样本取自股骨头的选定区域，包括负重区和非负重区的软骨和骨组织。软骨显示出表面病变，如糜烂和裂隙，以及深部病变，包括基质改变和软骨细胞增殖。关于软骨下骨增厚，我们注意到骨 - 软骨表面不规则，有骨组织增殖迹象。小梁在负重区增厚，在非负重区稀疏。松质骨不同深度有时存在空洞。我们的观察结果使我们得出结论，软骨病变是早熟的，分布广泛且相对独立于所考虑的股骨头区域，而骨组织改变似乎分布均匀且在时间上较晚出现。松质骨中的空洞可能会导致负荷改变和随之而来的骨畸形。
