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普拉马兹-沙茨支架冠状动脉内植入术与传统球囊血管成形术治疗慢性冠状动脉完全闭塞的结果比较。

Comparison of results of intracoronary implantation of the Plamaz-Schatz stent with conventional balloon angioplasty in chronic total coronary arterial occlusion.

作者信息

Mori M, Kurogane H, Hayashi T, Yasaka Y, Ohta S, Kajiya T, Takarada A, Yoshida A, Matsuda Y, Nakagawa K, Murata T, Yoshida Y, Yokoyama M

机构信息

Division of Cardiology, Himeji Cardiovascular Center, Japan.

出版信息

Am J Cardiol. 1996 Nov 1;78(9):985-9. doi: 10.1016/s0002-9149(96)00521-8.

Abstract

We compared angiographic and clinical outcomes after successful revascularization of chronic total coronary arterial occlusion with the placement of the Palmaz-Schatz stent (43 patients) and conventional balloon angioplasty (53 patients). After the procedure, the coronary stent led to a greater minimal lumen diameter than conventional balloon angioplasty (2.6 vs 1.7 mm, p < 0.001), resulting in a smaller residual stenosis (6.5% vs 36.7%, p < 0.001). At 6-month follow-up, there was no significant difference in late loss between the groups, resulting in a larger minimal lumen diameter at follow-up in the stent group (1.8 vs 1.1 mm, p < 0.001). The incidence of restenosis was lower in the stent group (27.9% vs 56.6%, p < 0.005). The frequency of the combination of myocardial infarction and coronary artery bypass graft surgery tended to be less in the stent group (2.3% vs 11.3%, P = 0.09). Placement of the Palmaz-Schatz stent improved left ventricular ejection fraction by 26% in patients who had reduced left ventricular function (p < 0.05), but conventional balloon angioplasty did not. Thus, placement of the Palmaz-Schatz stent provided a wider lumen than did conventional balloon angioplasty and, therefore, reduced the incidence of restenosis in chronic total coronary arterial occlusion. The lower restenosis rate of coronary stenting would be beneficial for long-term clinical outcome in patients with chronic total occlusion.

摘要

我们比较了使用Palmaz-Schatz支架(43例患者)和传统球囊血管成形术(53例患者)成功实现慢性冠状动脉完全闭塞血管重建后的血管造影和临床结果。术后,冠状动脉支架导致的最小管腔直径大于传统球囊血管成形术(2.6对1.7毫米,p<0.001),残余狭窄更小(6.5%对36.7%,p<0.001)。在6个月的随访中,两组间晚期管腔丢失无显著差异,导致支架组随访时的最小管腔直径更大(1.8对1.1毫米,p<0.001)。支架组再狭窄发生率更低(27.9%对56.6%,p<0.005)。支架组心肌梗死与冠状动脉搭桥手术联合发生的频率趋于更低(2.3%对11.3%,P = 0.09)。对于左心室功能降低的患者,植入Palmaz-Schatz支架使左心室射血分数提高了26%(p<0.05),但传统球囊血管成形术未起到这样的效果。因此,植入Palmaz-Schatz支架比传统球囊血管成形术提供了更宽的管腔,从而降低了慢性冠状动脉完全闭塞时的再狭窄发生率。冠状动脉支架较低的再狭窄率对慢性完全闭塞患者的长期临床结果有益。

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