Silberstein S D
Comprehensive Headache Center, Germantown Hospital and Medical Center, Philadelphia, PA 19144, USA.
Headache. 1996 Oct;36(9):547-55. doi: 10.1046/j.1526-4610.1996.3609547.x.
Divalproex sodium is an anticonvulsant agent approved for use either alone or in combination with other antiepileptic drugs for simple and complex absences seizures and mania. Four double-blind placebo-controlled studies have confirmed that divalproex sodium/valproate is an effective migraine treatment. In all of the clinical studies, whether open, retrospective, or placebo-controlled and double-blind, valproate was an effective preventive treatment for migraine. There was a reduction in the number of migraine attacks, and migraine duration and intensity were also reduced in some instances. It is equally as effective in patients with severe frequent migraines as in those with less severe migraines. In clinical trials, the most frequent adverse events reported by patients treated with divalproex sodium were nausea, asthenia, dyspepsia, dizziness, somnolence, and diarrhea, with most adverse events being mild to moderate in severity.
丙戊酸钠是一种抗惊厥药物，已被批准单独使用或与其他抗癫痫药物联合用于治疗单纯性和复杂性失神发作以及躁狂症。四项双盲安慰剂对照研究证实，丙戊酸钠是一种有效的偏头痛治疗药物。在所有临床研究中，无论研究类型是开放性、回顾性的，还是安慰剂对照和双盲的，丙戊酸都是偏头痛的有效预防性治疗药物。偏头痛发作次数减少，在某些情况下，偏头痛持续时间和强度也有所降低。它对严重频繁偏头痛患者和轻度偏头痛患者同样有效。在临床试验中，接受丙戊酸钠治疗的患者报告的最常见不良事件是恶心、乏力、消化不良、头晕、嗜睡和腹泻，大多数不良事件的严重程度为轻度至中度。
