Motohashi N, Kawase M, Kurihara T, Hevér A, Nagy S, Ocsocvszki I, Tanaka M, Molnár J
Department of Medicinal Chemistry, Meiji College of Pharmacy, Tokyo, Japan.
Anticancer Res. 1996 Sep-Oct;16(5A):2525-32.
10-[N-(Phthalimido)alkyl]-2-substituted-10H-phenothiazines and 1-(2-chloroethyl)-3-(2-substituted-10H-phenothiazin-10-yl)alkyl-1- ureas were synthesized and found to have antiproliferative effects on human HEp-2 and L5178Y cell cultures. The multi-drug resistant subline of mouse lymphoma was sensitive to the reversal effects of some 10-[N-(phthalimido)alkyl]-2-substituted-10H-phenothiazines, while 1-(2-chloro-ethyl)-3-(2-substituted-10H-phenothiazin-10-yl)alkyl-1 -ureas were less effective but had a similar degree of antiproliferative effect on both cell lines.
合成了10 - [N -（邻苯二甲酰亚胺基）烷基] - 2 -取代 - 10H -吩噻嗪和1 -（2 -氯乙基）- 3 -（2 -取代 - 10H -吩噻嗪 - 10 -基）烷基 - 1 -脲，并发现它们对人HEp - 2和L5178Y细胞培养物具有抗增殖作用。小鼠淋巴瘤的多药耐药亚系对某些10 - [N -（邻苯二甲酰亚胺基）烷基] - 2 -取代 - 10H -吩噻嗪的逆转作用敏感，而1 -（2 -氯乙基）- 3 -（2 -取代 - 10H -吩噻嗪 - 10 -基）烷基 - 1 -脲效果较差，但对两种细胞系具有相似程度的抗增殖作用。
