Moriuchi S, Shimizu K, Miyao Y, Hayakawa T
Department of Neurosurgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, The Center for Adult Diseases, Japan.
Anticancer Res. 1996 Sep-Oct;16(5A):2687-92.
Medulloblastoma is the most common primitive neuroectodermal tumor (PNET) of the central nervous system. Standard whole neuroaxis radiation prolongs survival, but causes mental retardation and growth disturbance. It is important to find appropriate prognostic indicators for medulloblastoma in children. We assessed the prognostic values of N-myc expression in medulloblastoma. Nineteen medulloblastoma or supratentorial PNET (SPNET) patients (15 males and 4 females) were immunohistochemically investigated for N-myc expression. Sixteen patients were N-myc-positive, and three were N-myc-negative. N-myc-positive patients had a tendency towards a poor outcome (P = 0.1125). N-myc-negative tumors were more differentiated towards glial lineage than N-myc-positive tumors. N-myc-negative and GFAP-positive patients (n = 2) tended to survive N-myc-positive and GFAP-negative patients (n = 13). In medulloblastoma and SPNET patients, N-myc expression may become an appropriate indicator of poor prognosis and primitive cell differentiation.
髓母细胞瘤是中枢神经系统最常见的原始神经外胚层肿瘤（PNET）。标准的全神经轴放疗可延长生存期，但会导致智力发育迟缓及生长障碍。寻找儿童髓母细胞瘤合适的预后指标很重要。我们评估了N - myc在髓母细胞瘤中的预后价值。对19例髓母细胞瘤或幕上PNET（SPNET）患者（15例男性，4例女性）进行免疫组化检测N - myc表达情况。16例患者N - myc呈阳性，3例呈阴性。N - myc阳性患者预后有较差的倾向（P = 0.1125）。与N - myc阳性肿瘤相比，N - myc阴性肿瘤向神经胶质谱系分化程度更高。N - myc阴性且胶质纤维酸性蛋白（GFAP）阳性的患者（n = 2）比N - myc阳性且GFAP阴性的患者（n = 13）更倾向于存活。在髓母细胞瘤和SPNET患者中，N - myc表达可能成为预后不良及原始细胞分化的合适指标。
