长春新碱对人体葡萄糖诱导的胰岛素分泌的影响。
Effect of vincristine on glucose-induced insulin secretion in man.
作者信息
Caviezel F, Poli M, Pozza G
出版信息
Experientia. 1977 Jul 15;33(7):970-1. doi: 10.1007/BF01951311.
PMID:891791
Abstract
60 min after the injection of therapeutic doses of vincristine for cancer chemotherapy, there is a reduction of the total (40%) and of the acute phase (43%) areas of insulin secretion inductedby 5-g i.v glucose load, and the constant of gllcose utilization is reduced by 25%. No differences are observed after 3 5-g i.v. glucose loads given at hourly intervals in control subjects.
摘要
在注射用于癌症化疗的治疗剂量长春新碱60分钟后，静脉注射5克葡萄糖负荷诱导的胰岛素分泌总量减少40%，急性期分泌面积减少43%，葡萄糖利用常数降低25%。在对照组受试者中，每小时静脉注射3次5克葡萄糖负荷后未观察到差异。
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