Avitall B, Naimi S, Levine H J, Mieszala J
J Electrocardiol. 1979 Jul;12(3):271-7. doi: 10.1016/s0022-0736(79)80060-6.
Strength-interval curves and conduction times were determined in anesthetized dogs during and following myocardial ischemia using a computerized system capable of determining a 5 point strength-interval curve with conduction times within 20 seconds. At the peak incidence of ligation arrhythmias (5 minutes of ischemia), the falling limb of the strength-interval curve was shifted to the left and conduction time was prolonged, while at 15 minutes of ischemia, the strength-interval was shifted upward and conduction times had returned toward control. Lidocaine enhanced the upward shift of the strength-interval curve, contributing to the electrical stability of the myocardium during this phase of ischemia. During the first minute following abrupt reperfusion of the ischemic zone, there was a slight downward shift of the early part of the strength-interval curve, and conduction times tended to be shorter than control. Lidocaine enhanced the electrophysiological alterations following abrupt reperfusion; that is, it reduced excitation thresholds and increased the tendency to superconductivity. Thus, lidocaine enhanced electrical stability during acute ischemia but tended to exaggerate electrophysiologic defects observed during abrupt reperfusion.
在麻醉犬心肌缺血期间及之后，使用能够在20秒内测定5点强度 - 间期曲线及传导时间的计算机系统，测定强度 - 间期曲线和传导时间。在结扎性心律失常的高峰发生率时（缺血5分钟），强度 - 间期曲线的下降支向左移位，传导时间延长，而在缺血15分钟时，强度 - 间期向上移位，传导时间已恢复至接近对照水平。利多卡因增强了强度 - 间期曲线的向上移位，有助于缺血此阶段心肌的电稳定性。在缺血区突然再灌注后的第一分钟内，强度 - 间期曲线早期部分有轻微向下移位，传导时间往往比对照短。利多卡因增强了突然再灌注后的电生理改变；也就是说，它降低了兴奋阈值并增加了超传导性倾向。因此，利多卡因在急性缺血期间增强了电稳定性，但往往会夸大突然再灌注期间观察到的电生理缺陷。
