Awadalla H N, Sadaka H A
Department of Parasitology, Faculty of Medicine, Alexandria University, Egypt.
J Egypt Soc Parasitol. 1996 Dec;26(3):601-8.
Acanthamoeba culbertsoni is one of the free-living amoebae which are known to be pathogenic to man, causing granulomatous amoebic encephalitis (GAE). In this study, Acanthamoeba culbertsoni was isolated from a water sample of El-Mahmoudia Canal in Alexandria, in July-1993. This was used to infect mice intranasally to study the histopathological picture of the brain and lungs. The neuropathological features consisted of chronic granulomatous encephalitis in which cysts and trophozoites were found. Associated Acanthamoeba pneumonitis with massive consolidation was also observed. Congenital infection of offsprings was reported for the first time in this study.
卡氏棘阿米巴是一种已知可致人类致病的自由生活阿米巴，可引起肉芽肿性阿米巴脑炎（GAE）。在本研究中，1993年7月从亚历山大港马赫穆迪运河的水样中分离出卡氏棘阿米巴。将其经鼻内接种感染小鼠，以研究脑和肺的组织病理学情况。神经病理学特征包括慢性肉芽肿性脑炎，其中发现了包囊和滋养体。还观察到伴有大片实变的棘阿米巴肺炎。本研究首次报道了子代的先天性感染。
