Chen C J, Yen J H, Tsai W C, Lin M B, Hsu S C, Tsai J J, Lin H C, Lu S N, Liu G C, Lin S F, Liu H W
Department of Internal Medicine, Kaohsiung Medical College, Taiwan, Republic of China.
Kaohsiung J Med Sci. 1996 Oct;12(10):567-72.
To study bone mineral density (BMD) in premenopausal adult female patients with systemic lupus erythematosus (SLE) and its relation with clinical parameters, 56 SLE patients (mean age 31 years, mean disease duration 6.3 years) and 15 normal controls were studied. BMD at the lumbar vertebrae (L2-L4) was measured by dual energy X-ray absorptiometry (DEXA). Classification of BMD was made according to the WHO criteria in 1994. Correlation between BMD and clinical parameters was calculated. It was found BMD in the SLE patients (0.942 +/- 0.136 g/cm2) was lower than in the control group (1.055 +/- 0.080 g/cm2) (P < 0.01). According to the WHO criteria, 17 patients (30%) had normal BMD, 22 patients (40%) had osteopenia and 17 patients (30%) had osteoporosis. BMD was inversely correlated with disease duration in SLE patients (p < 0.005). The minimal disease duration for a female SLE patient to develop osteopenia was 3.5 years. In conclusion, SLE patients have lower lumbar BMD than normal controls. SLE patients with longer disease duration have lower BMD. In order to achieve early prevention of osteoporosis, we suggest that female SLE patients with disease duration for more than 3.5 years should take a BMD examination.
为研究绝经前成年女性系统性红斑狼疮（SLE）患者的骨密度（BMD）及其与临床参数的关系，对56例SLE患者（平均年龄31岁，平均病程6.3年）和15名正常对照者进行了研究。采用双能X线吸收法（DEXA）测量腰椎（L2-L4）的骨密度。根据1994年世界卫生组织标准对骨密度进行分类。计算骨密度与临床参数之间的相关性。结果发现，SLE患者的骨密度（0.942±0.136g/cm²）低于对照组（1.055±0.080g/cm²）（P<0.01）。根据世界卫生组织标准，17例患者（30%）骨密度正常，22例患者（40%）骨量减少，17例患者（30%）骨质疏松。SLE患者的骨密度与病程呈负相关（p<0.005）。女性SLE患者发生骨量减少的最短病程为3.5年。总之，SLE患者的腰椎骨密度低于正常对照者。病程较长的SLE患者骨密度较低。为了实现骨质疏松症的早期预防，我们建议病程超过3.5年的女性SLE患者应进行骨密度检查。
