Topilko P, Murphy P, Charnay P
Unité 368 de l'Institut National de la Santé et de la Recherche Médicale, Ecole Normale Supérieure, Paris, France.
Mol Cell Neurosci. 1996;8(2-3):71-5. doi: 10.1006/mcne.1996.0045.
During the past few years important advances have been realized in the understanding of the molecular and cellular mechanisms operating in the differentiation of Schwann cells from neural crest cells. In particular the development of in vitro culture systems has allowed the analysis of commitment to the Schwann cell lineage, identification of an intermediate between the neural crest cell and the Schwann cell, and initial analysis of the factors controlling determination and differentiation processes. These studies point in particular to major roles for neuregulins which appear to be involved in the control of cell survival, proliferation, and differentiation, as well as of gene expression at different levels of the pathway.
在过去几年中，我们对神经嵴细胞分化为施万细胞过程中所涉及的分子和细胞机制的理解取得了重要进展。特别是体外培养系统的发展，使得我们能够分析施万细胞谱系的定向分化，识别神经嵴细胞和施万细胞之间的中间细胞类型，并初步分析控制决定和分化过程的因素。这些研究特别指出了神经调节蛋白的主要作用，它们似乎参与了细胞存活、增殖和分化的控制，以及该通路不同水平上的基因表达调控。
