Khanna N, Chandramuki A, Desai A, Ravi V
Department of Microbiology, National Institute of Mental Health and Neuro Sciences, Bangalore, India.
J Med Microbiol. 1996 Nov;45(5):376-9. doi: 10.1099/00222615-45-5-376.
The incidence of cryptococcosis in patients with AIDS is significant. Predisposing factors, laboratory findings and outcome were assessed in 60 patients with cryptococcal infections of the central nervous system over a 17.5-year period (Jan. 1978-June 1995). Predisposing factors for cryptococcal infection were identified in 36 patients, with HIV infection being the commonest (18). Cryptococcal cultures were positive in all patients. India ink staining was positive in 48 patients and cryptococcal antigen was detected in 35 of 36 patients tested. Comparison of clinical and laboratory parameters between HIV-positive and HIV-negative patients showed that CSF cell response was poorer, culture of cryptococci from non-neural sites was more frequent and mortality was higher in the HIV-positive group. Although not statistically significant, concurrent systemic infections, especially tuberculosis, were more frequent in the HIV-positive group.
艾滋病患者中隐球菌病的发病率颇高。在17.5年期间（1978年1月至1995年6月），对60例中枢神经系统隐球菌感染患者的易感因素、实验室检查结果及预后进行了评估。36例患者确定了隐球菌感染的易感因素，其中最常见的是HIV感染（18例）。所有患者的隐球菌培养均呈阳性。48例患者印度墨汁染色呈阳性，36例接受检测的患者中有35例检测到隐球菌抗原。HIV阳性和HIV阴性患者临床及实验室参数的比较显示，HIV阳性组脑脊液细胞反应较差，非神经部位隐球菌培养更常见，死亡率更高。虽然无统计学意义，但HIV阳性组并发全身感染，尤其是结核病更为常见。
